Considerations and Strategies for
Oligonucleotide Manufacturing Scale-Up

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What You’ll Get from This Brochure

Built for You

Your facility is unique, so it only makes sense to have an inline buffer formulation system built for your specific needs. Our systems can meet almost any space, cost or performance requirement.

Oligonucleotide therapeutics are revolutionizing the way scientists target molecules that are beyond the reach of conventional drugs.

To keep up with oligonucleotide demand, manufacturing needs to shift toward larger-scale processes. But with this up-scaling process comes challenges that must be addressed.

Download our whitepaper today to discover key challenges and potential solutions for pivotal steps in the oligonucleotide manufacturing process.

Gain valuable insights from bioprocessing experts as they guide you through the oligonucleotide manufacturing process step-by-step.

  • In-depth overviews of the upstream and downstream oligonucleotide manufacturing processes

  • Facilities and equipment considerations to help you achieve sustainable chemistry practices

  • Workforce challenges and how automation helps to fill the skills gap created by a tight labor market

  • Detailed breakdowns of the unique challenges that arise during scale-up

  • Guidance on scale-up to maintain the target product quality attributes and yield

Here’s what’s inside:


Maximize Your Oligonucleotide Manufacturing Process

Asahi Kasei Bioprocess America, Inc.

1855 Elmdale Ave., Glenview, IL 60026, USA

Who is Asahi Kasei Bioprocess?

Asahi Kasei Bioprocess is trusted by the world’s leading manufacturers to produce preclinical, clinical, and validation batches of oligo drug substance. With 15 years of experience in oligonucleotide fluid management, we understand that oligonucleotides are a rather unique breed of therapeutic — chemically synthesized, yet much larger in size than classic small molecules.

Patented Technology

Our Pro-Yield™ recirculation blender technology is built into every MOTIV™ to boost the buffer response rate. That allows you to reach your target setpoints in seconds.

Continuous Processing

Automate the production of multiple process buffers to meet chromatography system demands by creating subroutines and stacking recipe segments for just-in-time delivery.

Ready to learn how to scale up batch production? Download our whitepaper for actionable insights from our in-house experts.