Cleavage and Deprotection Systems

Enhance oligo production safety and efficiency

C&D Systems

Streamline this key unit operation in oligonucleotide manufacturing with an intuitive system from our Cleavage and Deprotection (C&D) family of products. Our mid- to large-scale C&D Systems allow you to automate the cleavage and deprotection steps while increasing your synthesis capacity by freeing up the oligosynthesizer to focus on its core functions. Available in a broad range of flow rates, C&D Systems are designed to accommodate both DNA and RNA processes.

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Built For You.

Post-synthesis, the crude oligonucleotide must be cleaved from the solid support and conditioned for further downstream processing steps. Our C&D Systems are designed to accommodate both DNA and RNA processes with numerous in-process controls to automate steps.

Key Features

  • Automated system designed and purpose-built for cleavage and deprotection, freeing up your synthesizer.
  • Advanced process controls with monitoring and control by UV, conductivity, pressure, temperature, flow rate or volume.
  • Available with deprotection vessels for a turnkey solution.
  • OCELOT™ System Control – our latest universally plant-compatible automation software.
  • Chemically compatible with HF or other chemicals as required and rated for hazardous area use.
  • Customizable to meet your process and facility requirements.

Asahi Kasei Bioprocess C&D Systems can be designed for chemical compatibility with HF as needed. Systems are available with integrated deprotection vessels, or alternatively can be used with your existing vessel.

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Breadth of Configurations

Catalog No. Deprotection Vessel Working Volume Pressure Rating Metering Pump Flow Rate Material of Construction
CD020 20 L 6 bar 6 to 180 L/h 316L SS
CD100 100 L 6 bar 20 to 600 L/h 316L SS
CD350 350 L 6 bar 48 to 2000 L/h 316L SS

C&D Systems can be customized to meet specific user requirements for your manufacturing process:

  • Second metering pump and flowmeter constructed of Hastelloy
  • Upgrade from eight (8) to twelve (12) main inlet ports
  • Upgrade to column forward flow, backflow and bypass modes
  • Jacketed deprotection vessel (user-specified volume)
  • Upgrade from three (3) to four (4) outlet ports including recirculation
  • Local panel-mount Human-Machine Interface (HMI)