Asahi Static Compression
Synthesis Columns
Proven design for mid-scale and large-scale solid phase oligosynthesis.
Asahi SCS Column™
Mid- to large-scale oligosynthesis has moved from legacy mixed bed reactors to more efficient flow-through column formats. Our industry- leading Asahi SCS Column is the ideal choice for fixed bed height applications using swellable supports. Ranging from 10 to 100 cm i.d., Asahi SCS Columns have synthesized multiple compounds at various scales, including commercial batches.
Scalable. Proven. Ergonomic.
Active Flow Distribution
CAD-modeled “active” flow distribution generates uniform dispersal of amidites and reagents across the entire column surface, even for columns packed with short bed heights, resulting in maximum coupling efficiency.
Ideal for Swellable Solid Supports
The Asahi SCS Column offers versatility to perform manual bed height adjustments between 2 and 15 cm while leaving a user-defined gap between the support surface and the top plate frit to accommodate support swelling and prevent pressure spikes during synthesis.
SCS Ergo and SCS Lift Options
The Asahi SCS Column is now available with the convenient SCS Ergo stand for ergonomic 180º rotation, and a portable SCS Lift mounted on a specially designed A-frame to assist with removal of the top and bottom plates.
Other options include:
- Electropolishing
- Heating jackets
- IQ/OQ documentation and execution
- ASME Code stamp
- CE marking with compliance to Pressure Equipment Directive
Product Options
| Catalog No. | Column Dimensions | Pressure Rating | Adjustable Bed Height | Theoretical DNA Capacity* | Theoretical RNA Capacity** |
| SCS10 | 10 cm i.d. x 15 cm L | 20 bar | 2- 15 cm | 8-30 mmol | 4-18 mmol |
| SCS15 | 15cm i.d.x 15cm L | 20 bar | 2- 15cm | 40 – 70 mmol | 18-40 mmol |
| SCS20 | 20 cm i.d. x 15 cm L | 20 bar | 2- 15 cm | 70-130 mmol | 40 – 75 mmol |
| SCS30 | 30 cm i.d. x 15 cm L | 20 bar | 2- 15 cm | 130-280 mmol | 75- 160 mmol |
| SCS35 | 35 cm i.d. x 15 cm L | 20 bar | 2- 15cm | 200 – 380 mmol | 100-230 mmol |
| SCS40 | 40 cm i.d. x 15 cm L | 20 bar | 2- 15 cm | 280- 500 mmol | 160- 300 mmol |
| SCS45 | 45 cm i.d. x 15 cm L | 20 bar | 2- 15cm | 300-630 mmol | 190-380 mmol |
| SCS50 | 50 cm i.d. x 15 cm L | 20 bar | 2- 15 cm | 500-750 mmol | 300-470 mmol |
| SCS60 | 60 cm i.d. x 15 cm L | 20 bar | 2- 15cm | 0.75 -1 mol | 460 – 670 mmol |
| SCS70 | 70 cm i.d. x 15 cm L | 20 bar | 2- 15cm | 0.80-1.5 mol | 500 – 920 mmol |
| SCS80 | 80 cm i.d. x 15 cm L | 20 bar | 2-15 cm | 1 – 2 mol | 0.67-1.2 mol |
| SCS100 | 100cmi.d.x 15cm L | 20 bar | 2- 15cm | 2-3 mol | 1.2- 1.8 mol |
Note: SCS Ergo and SCS Lift options are available for SCS10 to SCS50 column sizes.
*Based on 200 μmol/g loading for DNA synthesis and maximum bed height of 10 cm.
**Based on 120 μmol/g loading for RNA synthesis and maximum bed height of 10 cm.
Capacity is approximate and depends on your process, bed height and solid support loading.