Liquid Chromatography Systems
Reproducible gradient formation and cutting-edge software for today’s preparative- to production-scale purifications.
Asahi Kasei Bioprocess has launched a line of large-scale gradient UHPLC Systems which operate at pressures up to 200 bar. Now, challenging peptide separations which require the use of 5 μm reverse-phase silica gel can be separated with consistent linear gradient formation and shorter run times.
Gradient Mixing Technologies
We offer a selection of proprietary and patent-pending gradient mixing technologies to permit you to reproducibly separate your target therapeutic at large-scale, whether it be via reverse-phase or normal phase gradient elutions.
Low Pressure Gradient Mixing
- Control valves proportion eluents
- Mixing is on low pressure side of pumps
Controller type: Adaptive PAT control or flow control
Eluent supply: Pressurized
Turndown: Up to 30X
Accuracy: ± 2%
Controller type: Adaptive PAT control or ow control
Eluent supply: Unpressurized/minimally pressurized
Turndown: Up to 90X
Accuracy: ± 2%
Software Designed For You
Off-the-shelf chromatography systems may provide familiar software, but have rigid hardware constraints; conversely, systems with customized hardware are typically burdened with cumbersome and dated software. You no longer have to compromise.
Industrial Flow Paths
Since peptides and other small molecules that require UHPLC Systems are purified in organic solvents, our cost-effective industrial design is well-suited for UHPLC Systems.
|Eluents||Mainly organic solvents|
|Process connections||Inlets/outlets: TC|
|Process connections||Internal: NPT & compression|
|Wetted MOC||316, 316Ti, 316L|
|Surface finish spec||None|
|Piping documentation||Material CofC only|
|Low point drains||No|
|Elastomers||PTFE, FFKM, FEP|
Freedom of Customization
Your unique purification processes or multi-product applications may require an UHPLC System that is different than the standard offerings. Our team of artisan engineers and designers will craft you a customized solution based on our standard UHPLC System platform.
- Number of inlet ports or fractions
- End-of-stream air sensors
- Sample injection loops
- Software customization
- Hazardous area ratings (NFPA and ATEX)
- Modified footprints to fit into tight spaces and within fume hoods
Equipment designed to respect your manufacturing needs
|Catalog No.||Flow Rate Range||Pressure Rating||Typical DAC Column Pairing|
|UPC060||6-60 L/h||200 bar||6- 15cmi.d.|
|UPC120||12- 120 L/h||200 bar||7.5 – 20 cm i.d.|
|UPC180||18- 180 L/h||200 bar||10- 20 cm i.d.|
|UPC240||24- 240 L/h||200 bar||10-30 cm i.d.|
|UPC360||36 – 360 L/h||200 bar||15-40 cm i.d.|
|UPC 600||60 – 600 L/h||200 bar||20-45 cm i.d.|
|UPC 900||90 – 900 L/h||200 bar||30 – 60 cm i.d.|