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CURSIV™ Liquid Chromatography

UHPLC System

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Product Overview

UHPLC System

Asahi Kasei Bioprocess has launched a line of large-scale gradient UHPLC Systems which operate at pressures up to 200 bar. Now, challenging peptide separations which require the use of 5 μm reverse-phase silica gel can be separated with consistent linear gradient formation and shorter run times.
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Consistent
Linear Gradient Formation
≤ 200 Barg
Pressure Rating
Shorter
Run Times

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Benefits

Industrial Flow Paths

Since peptides and other small molecules that require UHPLC Systems are purified in organic solvents, our cost-effective industrial design is well-suited for UHPLC Systems.

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These systems enable consistent linear gradient formation and shorter run times.
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Gradient Mixing Technologies

Classic Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Enhanced Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

applications

Freedom of Customization

Your unique purification processes or multi-product applications may require an UHPLC System that is different than the standard offerings. Our team of artisan engineers and designers will craft you a customized solution based on our standard UHPLC System platform.

Features include:

  • Number of inlet ports or fractions
  • End-of-stream air sensors
  • Pre-filters
  • Sample injection loops
  • Software customization
  • Hazardous area ratings (NFPA and ATEX)
  • Modified footprints to fit into tight spaces and within fume hoods

Resources

UHPLC System

Catalog No. Typical Flow Rate Range Pressure Rating Typical Column Pairing
LC-1-200 6 – 60 L/h 200 barg 10 – 15 cm i.d.
LC-2-200 12 – 120 L/h 200 barg 10 – 20 cm i.d.
LC-3-200 18 – 180 L/h 200 barg 10 – 20 cm i.d.
LC-4-200 24 – 240 L/h 200 barg 10 – 30 cm i.d.
LC-6-200 36 – 360 L/h 200 barg 15 – 35 cm i.d.
LC-10-200 60 – 600 L/h 200 barg 20 – 45 cm i.d.
LC-15-200 90 – 900 L/h 200 barg 30 – 60 cm i.d.

Publications and More

Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

 

What are the advantages of UHPLC Systems for peptide separations?

UHPLC Systems enable efficient and consistent peptide separations, offering shorter run times due to their ability to handle high pressures and smaller particle sizes in chromatography media.

What solvents are UHPLC Systems designed to work with?

These systems are well-suited for purification processes involving organic solvents, making them cost-effective and efficient for peptide and small molecule purifications.

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