VANTIJ™ Bioprocess Filtration

Ultrafiltration / Diafiltration TFF System

Product Overview

Ultrafiltration / Diafiltration TFF System

Our UF/DF TFF skids are built with the understanding that oligonucleotides are unique therapeutics, demanding specialized and robust equipment to maximize the potential of every batch.
30 LPM
Flow Rate
4 Barg
Operating Pressure
60L
Max Working Volume

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Benefits

Reliable and Scalable

Asahi Kasei Bioprocess meets the growing demand for oligonucleotide manufacturing with a comprehensive suite of equipment solutions. Our technology enables efficient synthesis, purification, and concentration, supporting reliable and scalable production worldwide.

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Industry-standard cassette-style filters in ergonomic rack.

Oligo Manufacturers – Built For You.

While a TFF system is not new to biopharmaceutical development, a system built exclusively to operate in hazardous area environments is. Our UF/DF TFF is designed and manufactured from the ground up to work seamlessly in an oligo manufacturing environment. With explosion-proof components and regional certifications, this TFF comes with the confidence that it can operate reliably even in harsh conditions

Setting the Standard

  • One ergonomically accessible cassette holder: up to 20 m2 surface area.
  • On-skid retentate tank: max working volume of 60L.
  • Operating flow rate: up to 30 LPM.
  • Operating pressure: up to 4 barg.
  • Suite of sensors: conductivity, pH, pressure, flow, UV.
  • Recirculation and feed pumps.
  • OCELOT™ System Control automation.

applications

Automation Features

All our automated systems run on the OCELOT™ System Control software platform, created to seamlessly integrate with your existing operations. Each UF/DF TFF system offers a range of automation features to enhance your synthesis processes:

  • Manual or automated control.
  • Automated CIP.
  • Seamless transfer between filtration and buffer flush (no process pause).
  • Modern, user-friendly HMI.
  • Browser-based method editor and batch reporting tool, including remote viewing/editing capabilities.
  • 21 CFR Part 11 compliance, with electronic signature and audit trail capabilities.
  • Export data, integrate via OPC UA, or direct communication with other controllers/DCS, and customize batch reports to meet your specific needs.

Resources

Ultrafiltration / Diafiltration TFF System

Product options available upon request.

Publications and More

Can the UF/DF TFF skid operate in hazardous environments?

Yes, our TFF system is designed to operate in hazardous environments. It includes explosion-proof components and regional certifications, providing reliable performance even in harsh conditions.

Is the UF/DF TFF skid suitable for both upstream and downstream processes?

Absolutely. The system can be used upstream prior to chromatography to enhance purification or downstream before lyophilization for concentration. It’s optimized for high performance and efficiency in both unit operations.

What types of filters does the UF/DF TFF skid support?

The system is compatible with widely available cassette-style filters, supporting up to 20 sqm of total filtration area.

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