Contact Sales
Contact Service
Request A Quote
THESYS™ Oligonucleotide Synthesis

C&D Systems

Download Data
Resources

Product Overview

C&D Systems

Streamline this key unit operation in oligonucleotide manufacturing with an intuitive system from our Cleavage and Deprotection (C&D) family of products. Our mid- to large-scale C&D Systems allow you to automate the cleavage and deprotection steps while increasing your synthesis capacity by freeing up the oligosynthesizer to focus on its core functions. Available in a broad range of flow rates, C&D Systems are designed to accommodate both DNA and RNA processes.
Request A Quote

Request a Demo

Understand the true meaning of our Built For You philosophy – request a demo to learn more about our equipment and capabilities.

Contact Us

Benefits

Built For You.

Post-synthesis, the crude oligonucleotide must be cleaved from the solid support and conditioned for further downstream processing steps. Our C&D Systems are designed to accommodate both DNA and RNA processes with numerous in-process controls to automate steps.

1 2
X
Designed to accommodate both DNA and RNA processes, offering versatility across different oligonucleotide manufacturing needs.
X
Available with flow rates ranging from 180 L/h to 2000 L/h, suitable for both clinical and commercial-scale manufacturing.
THESYS™ C&D Systems can be designed for chemical compatibility with hydrofluoric acid (HF) as needed. Systems are available with integrated deprotection vessels, or alternatively can be used with your existing vessel.

Key Features

  • Automated system designed and purpose-built for cleavage and deprotection, freeing up your synthesizer.
  • Advanced process controls with monitoring and control by UV, conductivity, pressure, temperature, flow rate or volume.
  • Available with deprotection vessels for a turnkey solution.
  • OCELOT™ System Control – our latest universally plant-compatible automation software.
  • Chemically compatible with HF or other chemicals as required and rated for hazardous area use.
  • Customizable to meet your process and facility requirements.

Resources

C&D Systems

Catalog No. Deprotection Vessel Working Volume Pressure Rating Metering Pump Flow Rate Material of Construction
CD020 20 L 6 barg 6 to 180 L/h 316L SS
CD100 100 L 6 barg 20 to 600 L/h 316L SS
CD350 350 L 6 barg 48 to 2000 L/h 316L SS
Note: This product may be subject to export control 

Publications and More

 

Why is automation of the cleavage and deprotection steps important?

Traditionally, these steps were handled manually or with repurposed equipment, which could be time-consuming and prone to errors. Automation ensures consistency, reduces manual intervention, and integrates these steps seamlessly into the overall manufacturing process, enhancing efficiency and reliability.

What scale of production can C&D Systems accommodate?

C&D Systems are available with flow rates ranging from 180 L/h to 2000 L/h, making them suitable for both mid- to large-scale production. This flexibility allows them to support both clinical and commercial-scale oligonucleotide manufacturing.

Are C&D Systems compatible with both DNA and RNA processes?

Yes, C&D Systems are designed to accommodate both DNA and RNA processes, providing versatility in therapeutic oligonucleotide production. This makes them ideal for a wide range of applications within the industry.

How does the automation of C&D Systems align with GMP manufacturing requirements?

C&D Systems are designed to operate with software-controlled systems that are validated for GMP manufacturing. This ensures that the cleavage and deprotection processes are not only automated but also comply with the stringent regulatory standards required for therapeutic oligonucleotide production.

Related Products

view all products

Contact Us

Let’s talk about your fluid management needs.

Newsletter Sign-Up