THESYS™ Oligonucleotide Synthesis

Oligosynthesizer

Product Overview

Oligosynthesizer

Asahi Kasei Bioprocess offers a suite of proven solid-phase flow-through oligosynthesizer options in the millimole (mmol) to mole (mol) range. Our patented synthesis technology has produced multiple DNA, RNA and duplex compounds at various scales, including validation batches.
Easily Paired
with our THESYS™ Columns:
ACS Column
SCS Column

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Benefits

Patented Valve Design

Expect improved full-length purity and reduced wash volumes with our patented zero-static (ZS) inlet valve manifolds. Multiple ZS inlet valve manifolds congregate the monomer and reagent to the pumps. Developed through computational fluid dynamics modeling, ZS inlet valve manifolds are multiport valves with low hold up volume to minimize carryover of amidite and reagents.

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Innovative valve design to ensure minimized phosphoramidite and reagent carryover from one step to the next.
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Advanced process controls with monitoring and control by UV, conductivity, density, pressure, flow rate or volume.

Scalable Oligosynthesis

Our oligosynthesizers are built for you and ensure seamless scale-up from other small-scale synthesizers with consistent full-length purity of your oligonucleotide. Figures 1 and 2 below show conductivity and UV trends, respectively, from a 40 mmol cGMP batch of RNA synthesis.

Resources

Oligosynthesizer

Catalog No. Approx. Scale Pressure Rating Typical Column Pairing
OS-03 Up to 190 mmol 10 barg Up to 30 cm i.d.
OS-04 Up to 480 mmol 10 barg Up to 40 cm i.d.
OS-06 Up to 1090 mmol 10 barg Up to 60 cm i.d.
OS-08 Up to 2185 mmol 10 barg Up to 85 cm i.d.
OS-12 Up to 4350 mmol 10 barg Up to 120 cm i.d.

Publications and More

What considerations should be made when scaling up oligonucleotide production using the THESYS™ Oligosynthesizer?

When scaling up production, factors such as reagent supply, synthesis duration, and process control parameters should be carefully managed. The THESYS™ Oligosynthesizer is designed to handle these challenges, offering smooth scalability from millimole to mole quantities without compromising on quality or efficiency.

Can the THESYS™ Oligosynthesizer be integrated into existing manufacturing workflows?

Yes, the THESYS™ Oligosynthesizer is designed for seamless integration into existing workflows. Its flexible design and the OCELOT™ System Control software allow it to interface with other equipment and automation systems, making it easy to incorporate into your current manufacturing processes.

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