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CURSIV™ Liquid Chromatography

MPLC System

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Product Overview

MPLC System

Many mid-sized therapeutics in the 4 to 15 kDa range, such as microbial-derived proteins and oligonucleotides, are purified using 15 to 40 μm chromatography media. Such processes generate higher backpressures than can be accommodated by a typical 6 or 10 bar system but don’t require the pressure rating and upfront capital cost of traditional preparative HPLC. For over a decade, Asahi Kasei Bioprocess has been a leader in 20 bar MPLC Systems for these applications.
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15 to 40 μm
Chromatography Media
≤ 20 Barg
Pressure Rating
Reverse-Phase
Gradient Elutions

Benefits

Industrial, Sanitary or Hygienic Flow Paths

For oligonucleotide or microbial-derived protein purifications that mainly utilize aqueous mobile phases with limited use of organics, or for highly potent active pharmaceutical ingredient (HP-API) purifications where minimized system hold-up is desired, our sanitary or hygienic flow paths are attractive options. Alternatively, our industrial flow path is the most cost-effective for small molecules.

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Gradient inlet parameters.
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Gradient Mixing Technologies

Classic Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps


Controller type: Adaptive PAT control or flow control

Eluent supply: Pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Enhanced Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps


Controller type: Adaptive PAT control or flow control

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

High Pressure Gradient Mixing

  • Pumps proportion eluents
  • Mixing is on high pressure side of pumps

Controller type: Flow control

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

Ternary Pressure Gradient Mixing

  • Three control valves proportion eluents

  • Mixing is on low pressure side of pumps
    Ideal for combination aqueous/organic elutions

Controller type: Adaptive PAT control or flow control

Eluent supply: Pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Resources

MPLC System

Catalog No. Typical Flow Rate Range Pressure Rating Typical Column Pairing
LC-1-20 6 – 60 L/h 20 barg 5 – 10 cm i.d.
LC-2-20 12 – 120L/h 20 barg 5 – 10 cm i.d.
LC-3-20 18 – 180 L/h 20 barg 5 – 10 cm i.d.
LC-4-20 24 – 240 L/h 20 barg 15 – 30 cm i.d.
LC-6-20 36 – 360 L/h 20 barg 15 – 40 cm i.d.
LC-10-20 60 – 600 L/h 20 barg 20 – 45 cm i.d.
LC-15-20 90 – 900 L/h 20 barg 30 – 60 cm i.d.
LC-20-20 120 – 1200 L/h 20 barg 30 – 80 cm i.d.
LC-40-20 240 – 2400 L/h 20 barg 40 – 100 cm i.d.

Publications and More

Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

What chromatography media are MPLC Systems compatible with?

MPLC Systems are designed to accommodate 15 to 40 µm chromatography media, which is commonly used for mid-sized therapeutic purification.

What types of gradient elution techniques do MPLC Systems support?

MPLC Systems support ion exchange and reverse-phase gradient elutions, offering reliable purification across different applications.

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