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THESYS® Oligonucleotide Synthesis

SCS Column

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Product Overview

SCS Column

Mid- to large-scale oligosynthesis has moved from legacy mixed bed reactors to more efficient flow-through column formats. Our industry-leading THESYS® SCS Column is the ideal choice for fixed bed height applications using swellable supports. Ranging from 10 to 100 cm i.d., THESYS® SCS Columns have synthesized multiple compounds at various scales, including commercial batches.
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Benefits

Ideal for Swellable Solid Supports

The THESYS® SCS Column offers versatility to perform manual bed height adjustments between 2 and 15 cm while leaving a user-defined gap between the support surface and the top plate frit to accommodate support swelling and prevent pressure spikes during synthesis.

1 2
X
Static compression synthesis column that has become ubiquitous with large-scale oligosynthesis – designed with a fixed but adjustable top plate, allowing the user to “set and forget” bed height.
X
Allows for a gap between the solid support and the top plate frit to accommodate swelling of polymeric support during the synthesis cycle, reducing the risk of column overpressure alarms.

SCS Ergo

The THESYS® SCS Column is now available with the convenient SCS Ergo stand for ergonomic 180º rotation, and a portable SCS Lift mounted on a specially designed A-frame to assist with removal of the top and bottom plates.

Other Options Include:

  • Electropolishing
  • IQ/OQ documentation and execution
  • ASME Code stamp
  • CE marking with compliance to Pressure Equipment Directive
SCS Column

Resources

SCS Column

Catalog No. Column Dimensions Pressure Rating Adjustable Bed Height Typical scale range in mmol for each column
SCS-10-15-20 10 cm ID x 15 cm L 20 barg 2 – 15 cm 0 – 30
SCS-15-15-20 15 cm ID x 15 cm L 20 barg 2 – 15 cm 5 – 65
SCS-20-15-20 20 cm ID x 15 cm L 20 barg 2 – 15 cm 5 – 120
SCS-25-15-20 25 cm ID x 15 cm L 20 barg 2 – 15 cm 10 – 190
SCS-30-15-20 30 cm ID x 15 cm L 20 barg 2 – 15 cm 15 – 270
SCS-35-15-20 35 cm ID x 15 cm L 20 barg 2 – 15 cm 20 – 370
SCS-40-15-20 40 cm ID x 15 cm L 20 barg 2 – 15 cm 25 – 145
SCS-45-15-20 45 cm ID x 15 cm L 20 barg 2 – 15 cm 35 – 605
SCS-50-15-20 50 cm ID x 15 cm L 20 barg 2 – 15 cm 45 – 750
SCS-60-15-20 60 cm ID x 15 cm L 20 barg 2 – 15 cm 60 – 1080
SCS-70-15-20 70 cm ID x 15 cm L 20 barg 2 – 15 cm 85 – 1470
SCS-80-15-20 80 cm ID x 15 cm L 20 barg 2 – 15 cm 110 – 1920
SCS-85-15-20 85 cm ID x 15 cm L 20 barg 2 – 15 cm 120 – 2170
SCS-100-15-20 100 cm ID x 15 cm L 20 barg 2 – 15 cm 170 – 3000

Publications and More

THESYS® Synthesis Columns Brochure

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The Buyers Guide to Oligonucleotide Synthesis

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The Oligonucleotide Checklist

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Diagrams available upon request.

Can the THESYS® SCS Column be scaled for different production volumes?

Yes, the SCS Column features a scalable design, with options ranging from 10 cm to 100 cm in internal diameter (i.d.). This flexibility allows you to easily adjust the column size based on your specific production volume requirements, whether for small-scale R&D or large-scale manufacturing.

How does the fixed bed height configuration in the SCS Column reduce the risk of overpressure?

The fixed bed height configuration minimizes the chances of column overpressure by maintaining consistent pressure distribution across the column. This design reduces the risk of system failures or product loss, ensuring a safer and more reliable synthesis process.

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