Proven design for mid-scale and large-scale solid phase oligosynthesis.
Asahi Kasei Bioprocess offers a suite of proven solid-phase flow-through oligosynthesizer options in the millimole (mmol) to mole (mol) range. Our patented synthesis technology has produced multiple DNA, RNA and duplex compounds at various scales, including validation batches.
Easily paired with our Asahi SCS Column™ or Asahi ACS Column™
Patented Valve Design
Expect improved full-length purity and reduced wash volumes with our patented zero-static (ZS) inlet valve manifolds. Multiple ZS inlet valve manifolds congregate the monomer and reagent to the pumps. Developed through computational fluid dynamics modeling, ZS inlet valve manifolds are multiport valves with low hold up volume to minimize carryover of amidite and reagents.
Our oligosynthesizers are built for you and ensure seamless scale-up from other small-scale synthesizers with consistent full-length purity of your oligonucleotide. Figures 1 and 2 below show conductivity and UV trends, respectively, from a 40 mmol cGMP batch of RNA synthesis.
The Asahi Oligosynthesizer™ was awarded Patent number EP1714695 by the European Patent Office.
|Catalog No.||Product Specification||Pressure Rating||Typical Asahi ACS or SCS Column Pairing|
|Synth30||3-30 mmol*||10 bar||10-15 cm i.d. **|
|Synth100||10-100 mmol*||10 bar||10-30 cm i.d. **|
|Synth300||30-300 mmol*||10 bar||15-50 cm i.d. **|
|Synth1000||0.1-1 mol*||6 bar||30-90 cm i.d.**|
|Synth1500||0.15-1.5 mol*||5 bar||30-100 cm i.d. **|
|Synth2500||0.25-2.5 mol||5 bar||30-l00 cm i.d. **|
*Actual synthesis scale is dependent on solid support loading and packed bed height.
**Column pairing is dependent on loading of solid support.