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CURSIV™ Liquid Chromatography

HPLC System

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Product Overview

HPLC System

Classic small molecule and small protein purification processes utilizing 10 to 15 μm chromatography media will generate backpressures of 70 to 100 barg. Such applications typically require linear gradients to achieve the desired product purity. Our HPLC Systems meet the required pressure rating while offering an array of flexible gradient technology options to fit your needs—whether it is normal phase, reverse-phase or chiral chromatography.
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Industrial
and Sanitary Configurations
≤ 100 Barg
Pressure Rating
Flexible
Gradient Technology Options

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Benefits

Industrial, Sanitary or Hygienic Flow Paths

For oligonucleotide or microbial-derived protein purifications that mainly utilize aqueous mobile phases with limited use of organics, or for highly potent active pharmaceutical ingredient (HP-API) purifications where minimized system hold-up is desired, our sanitary or hygienic flow paths are attractive options. Alternatively, our industrial flow path is the most cost-effective for small molecules.
1 2
X
Fractionization table.
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For preparative- to production-scale purifications.
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Gradient Mixing Technologies

High Pressure Gradient Mixing

  • Pumps proportion eluents
  • Mixing is on high pressure side of pumps

 

Controller type: Flow control

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

Ternary Pressure Gradient Mixing

  • Three control valves proportion eluents
  • Mixing is on low pressure side of pumps
  • Ideal for combination aqueous/organic elutions

 

Controller type: Adaptive PAT control or ow control

Eluent supply: Pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Classic Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Enhanced Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

High Pressure Gradient Mixing

  • Pumps proportion eluents
  • Mixing is on high pressure side of pumps

 

Controller type: Flow control

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

Ternary Pressure Gradient Mixing

  • Three control valves proportion eluents
  • Mixing is on low pressure side of pumps
  • Ideal for combination aqueous/organic elutions

 

Controller type: Adaptive PAT control or ow control

Eluent supply: Pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Classic Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 30X

Accuracy: ± 2%

Enhanced Low Pressure Gradient Mixing

  • Control valves proportion eluents
  • Mixing is on low pressure side of pumps

 

Controller type: Adaptive PAT control or flow control 

Eluent supply: Unpressurized/minimally pressurized

Turndown: Up to 90X

Accuracy: ± 2%

Resources

HPLC System

Catalog No. Typical Flow Rate Range Pressure Rating Typical Column Pairing
LC-1-100 6 – 60 L/h 100 barg 10 – 15 cm i.d.
LC-2-100 12 – 120 L/h 100 barg 10 – 20 cm i.d.
LC-3-100 18 – 180 L/h 100 barg 10 – 20 cm i.d.
LC-4-100 24 – 240 L/h 100 barg 10 – 30 cm i.d.
LC-6-100 36 – 360 L/h 100 barg 15 – 40 cm i.d.
LC-10-100 60 – 600 L/h 100 barg 20 – 45 cm i.d.
LC-15-100 90 – 900 L/h 100 barg 30 – 60 cm i.d.
LC-20-100 120 – 1200 L/h 100 barg 30 – 80 cm i.d.
LC-40-100 240 – 2400 L/h 100 barg 40 – 100 cm i.d.

Publications and More

CURSIV™ Liquid Chromatography Systems Brochure

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Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

Our systems are engineered to meet your requirements. More fraction outlets are available. Ask about our customizations.

 

What chromatography modes are supported by the HPLC Systems?

The systems support normal phase, reverse-phase, and chiral chromatography, providing versatile options to meet various purification needs

What are the benefits of flexible gradient technology in HPLC Systems?

Flexible gradient technology allows for precise control over the purification process, making it easier to achieve the desired product purity. This is particularly important in applications requiring linear gradients.

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