MOTIV® Inline Buffer Formulation

3-Pump Inline Buffer Formulation System

Product Overview

3-Pump Inline Buffer Formulation System

Designed to fit within tighter space and budget constraints, our patented 3-pump IBF Systems leverage process analytical technology (PAT) to generate precise and reproducible buffers for a consistent yield and recovery of your biologic product.
1,000 L/h
Clinical Manufacturing
5,000 – 10,000 L/h
Large Scale Manufacturing
15,000 L/h
Extra Scale Manufacturing

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Benefits

Patented Pro-Yield™ Recirculation Blender Technology

All MOTIV® systems include our patented, Pro-Yield recirculation blending technology to shorten the buffer adjustment response rate. The dynamic, single-pass mixer efficiently blends your liquid streams inline – regardless of flow rate or viscosity – to allow for a faster setpoint target and faster washout volumes.

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One larger pump is used to deliver the dilutant, typically WFI or purified water, into the system
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Two smaller pumps can deliver buffer concentrate and an acid or base modifier, respectively

Video Library

Efficient Buffer Production

With MOTIV® 3, you can leverage stock buffer concentrates and pH modifiers to produce high-quality buffers on demand, within as short as 15 seconds from system start-up. After use, the system can be rinsed down in under a minute.

Continuous Processes

Create subroutines and stack recipe segments to produce multiple process buffers unattended and sequentially, just-in-time to feed continuous chromatography systems.

Resources

3-Pump Inline Buffer Formulation System

MOTIV 310 MOTIV 312 MOTIV 325 MOTIV 350
Flow Rate 60 — 1000 L/h  120— 1200 L/h Up to 2500 L/h 500 – 5000 L/h
Form Factor Mobile Console Format Space-Saving Skid Format Space-Saving Skid Format Space-Saving Skid Format
Use Clinical Scale Manufacturing Large Scale Manufacturing Large Scale Manufacturing Large Scale Manufacturing
Dilution Factor Up to 20x Dilution Up to 20x Dilution Up to 20x Dilution Up to 20x Dilution
Dimensions 770mm x 1500mm x 1610mm 770mm x 1500mm x 1610mm 1370mm x 762mm x 1854mm 1990mm x 1220mm x 1880mm

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What are the benefits of using the MOTIV® 3-pump IBF System for buffer production?

The MOTIV® 3-pump IBF System allows for high-quality buffer production on demand, with buffer generation starting within a minute of system start-up. Additionally, the system can be rinsed down in under a minute after use, optimizing both production efficiency and equipment maintenance.

Can the MOTIV® 3 be used for continuous processes?

Yes, the MOTIV® 3 supports continuous processes by allowing users to create subroutines and stack recipe segments. This feature enables the production of multiple process buffers sequentially and unattended, making it ideal for feeding continuous chromatography systems just-in-time.

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