Contact Sales
Contact Service
Request A Quote
THESYS® Oligonucleotide Synthesis

ACS Column

Download Data
Resources
THESYS ACS

Product Overview

ACS Column

The THESYS® ACS Column is ideal for rigid solid supports that don’t swell. This flow-through synthesis column offers “hoist-free” operation for easy frit removal and simplified column packing and unpacking via axial compression with an integrated piston. The piston is always in contact with the packed solid support without a gap.
Request A Quote

Request a Demo

Understand the true meaning of our Built For You™ philosophy – request a demo to learn more about our equipment and capabilities.
Contact Us

Benefits

Active Flow Distribution

CAD-modeled “active” flow distribution generates uniform dispersal of amidites and reagents across the entire column surface, even for columns packed with short bed heights, resulting in maximum coupling efficiency.

1 2
X
Distributor plate with CAD-modeled “active” flow distribution for uniform dispersal of amidites and reagents.
X
Slurry inlet port to permit closed transfer of slurried solid support prior to packing.

A Range of Features and Options

The THESYS® ACS Column includes a slurry inlet port to simplify the loading of your solid support. Its slurry outlet port can be used to unpack your solid support, and also to take samples of your support during the synthesis process after depressurizing the column.

Other Options Include:

  • Electropolishing
  • IQ/OQ documentation and execution
  • ASME Code stamp
  • CE marking with compliance to Pressure Equipment Directive
ACS Detail

Resources

ACS Column

Catalog No. Column Dimensions Pressure Rating Adjustable Bed Height Typical scale range in mmol for each column*
CPG Loading Polystyrene Loading
25 µmol/g 120 µmol/g 150 µmol/g 350 µmol/g
ACS-10-30-10 10 cm ID x 30 cm L 10 barg 4 – 15 cm 2 – 6 11 – 27 5 – 13 12 – 30
ACS-15-30-10 15 cm ID x 30 cm L 10 barg 4 – 15 cm 5 – 13 25 – 61 12 – 29 27 – 67
ACS-20-30-10 20 cm ID x 30 cm L 10 barg 4 – 15 cm 9 – 23 44 – 109 21 – 51 48 – 120
ACS-25-30-10 25 cm ID x 30 cm L 10 barg 4 – 15 cm 14 – 36 68 – 171 32 – 80 75 – 187
ACS-30-30-10 30 cm ID x 30 cm L 10 barg 4 – 15 cm 20 – 51 98 – 246 46 – 116 108 – 270
ACS-35-30-10 35 cm ID x 30 cm L 10 barg 4 – 15 cm 28 – 70 134 – 335 63 – 157 147 – 367
ACS-40-30-10 40 cm ID x 30 cm L 10 barg 4 – 15 cm 36 – 91 175 – 437 82 – 205 192 – 479
ACS-45-30-10 45 cm ID x 30 cm L 10 barg 4 – 15 cm 46 – 115 221 – 553 104 – 260 243 – 607
ACS-50-30-10 50 cm ID x 30 cm L 10 barg 4 – 15 cm 57 – 142 273 – 683 128 – 321 300 – 749
ACS-60-30-10 60 cm ID x 30 cm L 10 barg 4 – 15 cm 82 – 205 394 – 984 185 – 462 431 – 1079
ACS-70-30-10 70 cm ID x 30 cm L 10 barg 4 – 15 cm 112 – 279 536 – 1339 252 – 629 587 – 1468
ACS-80-30-10 80 cm ID x 30 cm L 10 barg 4 – 15 cm 146 – 364 700 – 1749 329 – 822 767 – 1918
ACS-85-30-10 85 cm ID x 30 cm L 10 barg 4 – 15 cm 165 – 411 790 – 1975 371 – 928 866 – 2165
ACS-100-30-10 100 cm ID x 30 cm L 10 barg 4 – 15 cm 288 – 569 1093 – 2733 514 – 1284 1199 – 2996

 

 

Note: Customized THESYS ACS columns are available upon request.
*Scale ranges assume 4-10 cm bed height range.

 

Publications and More

THESYS® Synthesis Columns Brochure

Download

The Buyers Guide to Oligonucleotide Synthesis

Download

The Oligonucleotide Checklist

Download

Diagrams available upon request.

What makes the THESYS® ACS Column suitable for rigid supports that don’t swell?

The Asahi THESYS® Column is specifically designed for rigid supports, offering a flow-through design that ensures efficient dispersion of reagents. The column’s piston remains in constant contact with the packed solid support, preventing any gaps and ensuring consistent performance.

How does the "hoist-free" operation of the THESYS® ACS Column simplify maintenance?

The “hoist-free” operation allows for easy frit removal and simplifies column packing and unpacking through axial compression of the integrated piston. This design eliminates the need for additional lifting equipment, making maintenance quicker and more convenient.

What are the benefits of the slurry inlet and outlet ports on the THESYS® ACS Column?

The slurry inlet port enables easy loading of solid supports, while the slurry outlet port allows for efficient unpacking of soft supports or sampling. These features streamline the process of column preparation and maintenance, saving time and effort.

What advantages does the integrated piston design of the THESYS® ACS Column offer?

The integrated piston design allows for axial compression, keeping the piston in continuous contact with the solid support. This eliminates gaps, reducing the risk of channeling and ensuring even reagent distribution throughout the synthesis process.

Related Products

view all products

Contact Us

Let’s talk about your fluid management needs.

Newsletter Sign-Up