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THESYS® Oligonucleotide Synthesis

SCS Column

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Product Overview

SCS Column

Mid- to large-scale oligosynthesis has moved from legacy mixed bed reactors to more efficient flow-through column formats. Our industry-leading THESYS® SCS Column is the ideal choice for fixed bed height applications using swellable supports. Ranging from 10 to 100 cm i.d., THESYS® SCS Columns have synthesized multiple compounds at various scales, including commercial batches.
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Benefits

Ideal for Swellable Solid Supports

The THESYS® SCS Column offers versatility to perform manual bed height adjustments between 2 and 15 cm while leaving a user-defined gap between the support surface and the top plate frit to accommodate support swelling and prevent pressure spikes during synthesis.

1 2
X
Static compression synthesis column that has become ubiquitous with large-scale oligosynthesis – designed with a fixed but adjustable top plate, allowing the user to “set and forget” bed height.
X
Allows for a gap between the solid support and the top plate frit to accommodate swelling of polymeric support during the synthesis cycle, reducing the risk of column overpressure alarms.

SCS Ergo

The THESYS® SCS Column is now available with the convenient SCS Ergo stand for ergonomic 180º rotation, and a portable SCS Lift mounted on a specially designed A-frame to assist with removal of the top and bottom plates.

Other Options Include:

  • Electropolishing
  • IQ/OQ documentation and execution
  • ASME Code stamp
  • CE marking with compliance to Pressure Equipment Directive
SCS Column

Resources

SCS Column

Catalog No. Column Dimensions Pressure Rating Adjustable Bed Height Typical scale range in mmol for each column*
CPG Loading Polystyrene Loading
25 µmol/g 120 µmol/g 150 µmol/g 350 µmol/g
SCS-10-15-20 10 cm ID x 15 cm L 20 barg 2 – 15 cm 2 – 6 11 – 27 5 – 13 12 – 30
SCS-15-15-20 15 cm ID x 15 cm L 20 barg 2 – 15 cm 5 – 13 25 – 61 12 – 29 27 – 67
SCS-20-15-20 20 cm ID x 15 cm L 20 barg 2 – 15 cm 9 – 23 44 – 109 21 – 51 48 – 120
SCS-25-15-20 25 cm ID x 15 cm L 20 barg 2 – 15 cm 14 – 36 68 – 171 32 – 80 75 – 187
SCS-30-15-20 30 cm ID x 15 cm L 20 barg 2 – 15 cm 20 – 51 98 – 246 46 – 116 108 – 270
SCS-35-15-20 35 cm ID x 15 cm L 20 barg 2 – 15 cm 28 – 70 134 – 335 63 – 157 147 – 367
SCS-40-15-20 40 cm ID x 15 cm L 20 barg 2 – 15 cm 36 – 91 175 – 437 82 – 205 192 – 479
SCS-45-15-20 45 cm ID x 15 cm L 20 barg 2 – 15 cm 46 – 115 221 – 553 104 – 260 243 – 607
SCS-50-15-20 50 cm ID x 15 cm L 20 barg 2 – 15 cm 57 – 142 273 – 683 128 – 321 300 – 749
SCS-60-15-20 60 cm ID x 15 cm L 20 barg 2 – 15 cm 82 – 205 394 – 984 185 – 462 431 – 1079
SCS-70-15-20 70 cm ID x 15 cm L 20 barg 2 – 15 cm 112 – 279 536 – 1339 252 – 629 587 – 1468
SCS-80-15-20 80 cm ID x 15 cm L 20 barg 2 – 15 cm 146 – 364 700 – 1749 329 – 822 767 – 1918
SCS-85-15-20 85 cm ID x 15 cm L 20 barg 2 – 15 cm 165 – 411 790 – 1975 371 – 928 866 – 2165
SCS-100-15-20 100 cm ID x 15 cm L 20 barg 2 – 15 cm 288 – 569 1093 – 2733 514 – 1284 1199 – 2996

 

Note: Customized THESYS SCS columns are available upon request.
*Scale ranges assume 4-10 cm bed height range.

Publications and More

THESYS® Synthesis Columns Brochure

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The Buyers Guide to Oligonucleotide Synthesis

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The Oligonucleotide Checklist

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Diagrams available upon request.

Can the THESYS® SCS Column be scaled for different production volumes?

Yes, the SCS Column features a scalable design, with options ranging from 10 cm to 100 cm in internal diameter (i.d.). This flexibility allows you to easily adjust the column size based on your specific production volume requirements, whether for small-scale R&D or large-scale manufacturing.

How does the fixed bed height configuration in the SCS Column reduce the risk of overpressure?

The fixed bed height configuration minimizes the chances of column overpressure by maintaining consistent pressure distribution across the column. This design reduces the risk of system failures or product loss, ensuring a safer and more reliable synthesis process.

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