CURSIV™ Liquid Chromatography

DAC MPLC Column

Product Overview

DAC MPLC Column

Many mid-sized therapeutics in the 4 to 15 kDa range, such as microbial- derived proteins and oligonucleotides, are purified using 15 to 40 μm chromatography media. Such processes generate higher backpressures than can be accommodated by a typical 6 or 10 bar column but don’t require the pressure rating and upfront capital cost of traditional preparative HPLC. For over a decade, Asahi Kasei Bioprocess has been a leader in 20 bar DAC MPLC Columns for these applications.
≤ 20 Barg
Pressure Rating
50 & 70 cm
Stroke Length Available
Ideal
For Clean Rooms

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Benefits

Pack Your Column in Minutes

Transfer slurry into the column and reproducibly piston-pack your chromatography media in minutes. When it is time to unpack your column, use the same piston to easily push the media out of the column.

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Fully moveable piston to achieve precise bed height
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Many oligonucleotides or small protein purification generate back pressure less than 20 bar. When a 20 bar column will be sufficient, MPLC columns provide the benefits associated with dynamic axial compression.

Active Flow Distribution

CAD-modeled “active” flow distribution generates uniform dispersal of your product and eluents across the entire column surface, even for columns packed with short bed heights, resulting in maximum chromatographic resolving power.

Greater Flexibility

Our DAC MPLC Columns are available with fully separated hydraulics. Columns with similar pressure ratings and internal diameters can be operated with a single hydraulic cart when the columns are not in use simultaneously. This unique feature reduces capital costs and maximizes resource allocation.

applications

Enjoy the Freedom of Customization

Several options are available so that you can customize your column to your particular application needs:

Features include:

  • Electropolishing
  • ASME code stamp
  • CE Pressure Equipment Directive compliance
  • IQ/OQ qualification package

Resources

DAC MPLC Column

Catalog No. Column Dimensions Pressure Rating
MP15x50 15 cm i.d. x 50 cm L 20 barg
MP15x70 15 cm i.d. x 70 cm L 20 barg
MP17x50 17 cm i.d. x 50 cm L 20 barg
MP17x70 17 cm i.d. x 70 cm L 20 barg
MP20x50 20 cm i.d. x 50 cm L 20 barg
MP20x70 20 cm i.d. x 70 cm L 20 barg
MP30x50 30 cm i.d. x 50 cm L 20 barg
MP30x70 30 cm i.d. x 70 cm L 20 barg
MP40x50 40 cm i.d. x 50 cm L 20 barg
MP40x70 40 cm i.d. x 70 cm L 20 barg
MP45x50 45 cm i.d. x 50 cm L 20 barg
MP45x70 45 cm i.d. x 70 cm L 20 barg
MP50x50 50 cm i.d. x 50 cm L 20 barg
MP50x70 50 cm i.d. x 70 cm L 20 barg
MP60x50 60cm i.d. x 50 cm L 20 barg
MP60x70 60 cm i.d. x 70 cm L 20 barg
MP80x50 80 cm i.d. x 50 cm L 20 barg
MP80x70 80 cm i.d. x 70 cm L 20 barg
MP100x50 100 cm i.d. x 50 cm L 20 barg
MP100x70 100 cm i.d. x 70 cm L 20 barg
MP120x50 120 cm i.d. x 50 cm L 20 barg
MP120x70 120 cm i.d. x 70 cm L 20 barg

Publications and More

Diagrams available upon request.

What pressure rating do DAC MPLC Columns support?

These columns are rated for 20 barg, providing the necessary pressure handling for processes involving 15 to 40 µm chromatography media.

What materials are used in the construction of DAC MPLC Columns?

The columns are constructed with 316L stainless steel and are equipped with highly fluorinated, FDA-compliant seals. These materials are compatible with both organic and aqueous mobile phases, ensuring robustness and compliance with industry standards. Full material traceability is provided for all stainless steel product contact parts.

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